:root {
  --navy-950: #061326;
  --navy-900: #0a1d36;
  --navy-800: #102b4d;
  --ink: #10243d;
  --muted: #60728a;
  --paper: #f7f9fc;
  --white: #ffffff;
  --line: rgba(16, 43, 77, .13);
  --cyan: #4ee1e5;
  --blue: #5f82ff;
  --coral: #fa8c79;
  --lime: #d4f582;
  --shadow: 0 24px 70px rgba(11, 37, 74, .12);
  --ease-out: cubic-bezier(.23, 1, .32, 1);
}

* { box-sizing: border-box; }
html { scroll-behavior: smooth; }
body {
  margin: 0;
  background: var(--paper);
  color: var(--ink);
  font-family: Inter, ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
  line-height: 1.55;
  -webkit-font-smoothing: antialiased;
}
body.nav-open { overflow: hidden; }
a { color: inherit; text-decoration: none; }
button, input, textarea { font: inherit; }
button { border: 0; }
img { display: block; max-width: 100%; }

.skip-link {
  position: fixed; left: 1rem; top: -5rem; z-index: 99; padding: .7rem 1rem;
  background: var(--lime); color: var(--navy-950); border-radius: 999px; font-weight: 700;
}
.skip-link:focus { top: 1rem; }

.container { width: min(1180px, calc(100% - 3rem)); margin: 0 auto; }
.narrow { width: min(760px, calc(100% - 3rem)); margin: 0 auto; }
.eyebrow {
  display: inline-flex; align-items: center; gap: .6rem; color: var(--blue); font-size: .72rem;
  font-weight: 800; letter-spacing: .16em; text-transform: uppercase;
}
.eyebrow::before { content: ""; display: inline-block; width: 22px; height: 2px; background: currentColor; }
.display { font-family: Georgia, "Times New Roman", serif; font-weight: 400; letter-spacing: -.045em; }
.section { padding: 7.5rem 0; }
.section-sm { padding: 4.5rem 0; }
.section-title { max-width: 720px; margin: 1rem 0 1.35rem; font-size: clamp(2.4rem, 5vw, 4.7rem); line-height: .98; }
.section-intro { max-width: 640px; color: var(--muted); font-size: 1.05rem; }
.center { text-align: center; margin-left: auto; margin-right: auto; }

.site-header {
  position: absolute; top: 0; left: 0; right: 0; z-index: 20;
  color: var(--white); transition: background .25s var(--ease-out), color .25s var(--ease-out), box-shadow .25s var(--ease-out);
}
.site-header.scrolled { position: fixed; background: rgba(247, 249, 252, .94); color: var(--ink); box-shadow: 0 8px 30px rgba(8, 28, 50, .08); backdrop-filter: blur(18px); }
.nav-wrap { min-height: 86px; display: flex; align-items: center; justify-content: space-between; gap: 2rem; }
.brand { display: inline-flex; align-items: center; gap: .7rem; font-size: .76rem; font-weight: 800; letter-spacing: .075em; line-height: 1.05; text-transform: uppercase; }
.brand-mark { width: 34px; height: 34px; border: 1.5px solid currentColor; border-radius: 50%; position: relative; display: grid; place-items: center; overflow: hidden; }
.brand-mark::before, .brand-mark::after { content: ""; position: absolute; width: 27px; height: 10px; border: 1.3px solid var(--cyan); border-radius: 50%; transform: rotate(48deg); }
.brand-mark::after { border-color: var(--coral); transform: rotate(-48deg); }
.brand-name { max-width: 155px; }
.nav-links { display: flex; align-items: center; gap: 1.75rem; font-size: .83rem; font-weight: 600; }
.nav-links a { position: relative; opacity: .8; transition: opacity .2s ease; }
.nav-links a:hover, .nav-links a[aria-current="page"] { opacity: 1; }
.nav-links a[aria-current="page"]::after { content: ""; position: absolute; height: 2px; left: 0; right: 0; bottom: -.55rem; background: var(--cyan); }
.nav-cta { border: 1px solid currentColor; padding: .65rem .95rem; border-radius: 999px; opacity: 1 !important; }
.nav-cta:hover { background: var(--white); color: var(--navy-900); border-color: var(--white); }
.site-header.scrolled .nav-cta:hover { background: var(--navy-900); color: var(--white); border-color: var(--navy-900); }
.menu-toggle { display: none; padding: .5rem; background: none; color: inherit; cursor: pointer; }
.menu-toggle span { display: block; width: 23px; height: 2px; background: currentColor; margin: 5px 0; transition: transform .2s ease, opacity .2s ease; }

.hero {
  position: relative; min-height: 780px; display: flex; align-items: center; overflow: hidden;
  background: var(--navy-950) url('assets/excision-hero.png') center right / cover no-repeat;
  color: var(--white);
}
.hero::before { content: ""; position: absolute; inset: 0; background: linear-gradient(90deg, rgba(6, 19, 38, .98) 0%, rgba(6, 19, 38, .84) 38%, rgba(6, 19, 38, .1) 75%); }
.hero::after { content: ""; position: absolute; inset: 0; opacity: .24; pointer-events: none; background-image: radial-gradient(rgba(255,255,255,.45) .65px, transparent .65px); background-size: 5px 5px; mix-blend-mode: overlay; }
.hero-inner { position: relative; z-index: 1; padding: 11rem 0 7rem; }
.hero-copy { max-width: 660px; }
.hero h1 { margin: 1.25rem 0 1.5rem; font-size: clamp(3.6rem, 8vw, 7.6rem); line-height: .89; }
.hero p { max-width: 560px; color: rgba(255,255,255,.76); font-size: 1.13rem; }
.hero-actions { display: flex; flex-wrap: wrap; gap: .8rem; margin-top: 2.35rem; }
.hero-meta { display: flex; flex-wrap: wrap; gap: 2rem; margin-top: 5rem; padding-top: 1.2rem; border-top: 1px solid rgba(255,255,255,.24); color: rgba(255,255,255,.68); font-size: .78rem; text-transform: uppercase; letter-spacing: .1em; }
.hero-meta strong { display: block; margin-bottom: .2rem; color: var(--white); font-size: 1rem; letter-spacing: 0; text-transform: none; }

.btn { display: inline-flex; align-items: center; justify-content: center; gap: .65rem; min-height: 50px; padding: .85rem 1.2rem; border-radius: 999px; font-size: .86rem; font-weight: 800; transition: transform .16s var(--ease-out), background .2s ease, border-color .2s ease, color .2s ease; cursor: pointer; }
.btn:active { transform: scale(.97); }
.btn-primary { background: var(--cyan); color: var(--navy-950); }
.btn-primary:hover { background: #8df1ed; transform: translateY(-2px); }
.btn-light { background: var(--white); color: var(--navy-900); }
.btn-light:hover { background: var(--lime); transform: translateY(-2px); }
.btn-ghost { border: 1px solid var(--line); color: var(--ink); }
.btn-ghost:hover { border-color: var(--blue); color: var(--blue); }
.btn-ghost-light { border: 1px solid rgba(255,255,255,.38); color: var(--white); }
.btn-ghost-light:hover { border-color: var(--white); background: rgba(255,255,255,.1); }
.arrow { font-size: 1.15rem; line-height: 0; }

.ticker { background: var(--lime); color: var(--navy-950); padding: .8rem 0; overflow: hidden; white-space: nowrap; }
.ticker-track { display: inline-flex; gap: 3rem; animation: ticker 24s linear infinite; font-size: .74rem; font-weight: 800; letter-spacing: .14em; text-transform: uppercase; }
.ticker-track span::before { content: "✦"; margin-right: 3rem; color: var(--coral); }
@keyframes ticker { from { transform: translateX(0); } to { transform: translateX(-50%); } }

.split { display: grid; grid-template-columns: .8fr 1.2fr; gap: clamp(3rem, 8vw, 8rem); align-items: start; }
.split.reverse { grid-template-columns: 1.2fr .8fr; }
.kicker-card { padding: 2rem; border-top: 1px solid var(--ink); }
.kicker-card h3 { margin: 0 0 .85rem; font-family: Georgia, "Times New Roman", serif; font-size: 1.7rem; font-weight: 400; line-height: 1.1; }
.kicker-card p { margin: 0; color: var(--muted); font-size: .96rem; }
.kicker-card .number { color: var(--coral); font-family: Georgia, serif; font-size: .85rem; }

.stat-band { background: var(--navy-900); color: var(--white); }
.stats { display: grid; grid-template-columns: repeat(4, 1fr); gap: 2rem; }
.stat { border-left: 1px solid rgba(255,255,255,.22); padding-left: 1.4rem; }
.stat strong { display: block; color: var(--cyan); font-family: Georgia, serif; font-size: clamp(2.25rem, 5vw, 4.3rem); font-weight: 400; line-height: 1; }
.stat span { display: block; max-width: 160px; margin-top: .7rem; color: rgba(255,255,255,.65); font-size: .78rem; text-transform: uppercase; letter-spacing: .09em; }

.feature-grid { display: grid; grid-template-columns: repeat(3, 1fr); gap: 1rem; margin-top: 3.2rem; }
.feature-card { min-height: 300px; padding: 1.8rem; background: var(--white); border: 1px solid var(--line); position: relative; overflow: hidden; transition: transform .25s var(--ease-out), box-shadow .25s var(--ease-out); }
.feature-card:hover { transform: translateY(-7px); box-shadow: var(--shadow); }
.feature-card::after { content: ""; position: absolute; width: 135px; height: 135px; right: -45px; bottom: -45px; border: 1px solid rgba(95,130,255,.27); border-radius: 50%; box-shadow: 0 0 0 19px rgba(95,130,255,.05), 0 0 0 39px rgba(95,130,255,.04); }
.feature-index { color: var(--coral); font-size: .75rem; font-weight: 800; letter-spacing: .1em; }
.feature-card h3 { margin: 4.6rem 0 .65rem; max-width: 210px; font-family: Georgia, serif; font-size: 1.7rem; font-weight: 400; line-height: 1.05; }
.feature-card p { max-width: 245px; color: var(--muted); font-size: .91rem; }

.callout { position: relative; overflow: hidden; padding: clamp(2.5rem, 6vw, 5.7rem); background: var(--navy-900); color: var(--white); }
.callout::after { content: ""; position: absolute; width: 370px; height: 370px; border: 1px solid rgba(78,225,229,.4); border-radius: 50%; right: -100px; top: -170px; box-shadow: 0 0 0 32px rgba(78,225,229,.05), 0 0 0 82px rgba(78,225,229,.035); }
.callout .section-title { max-width: 560px; margin-top: .9rem; }
.callout p { max-width: 540px; color: rgba(255,255,255,.7); }
.callout .btn { margin-top: 1.25rem; position: relative; z-index: 1; }

.page-hero { background: var(--navy-900); color: var(--white); padding: 11.5rem 0 5rem; position: relative; overflow: hidden; }
.page-hero::after { content: ""; position: absolute; width: 560px; height: 560px; border: 1px solid rgba(78,225,229,.26); border-radius: 50%; right: -130px; top: -220px; box-shadow: 0 0 0 34px rgba(78,225,229,.05), 0 0 0 90px rgba(78,225,229,.025); }
.page-hero .section-title { max-width: 830px; margin-bottom: 1rem; }
.page-hero p { max-width: 620px; color: rgba(255,255,255,.68); font-size: 1.08rem; }
.breadcrumb { display: flex; gap: .55rem; margin-bottom: 2rem; color: rgba(255,255,255,.55); font-size: .76rem; text-transform: uppercase; letter-spacing: .1em; }
.breadcrumb a:hover { color: var(--cyan); }

.dark-section { background: var(--navy-900); color: var(--white); }
.dark-section .section-intro { color: rgba(255,255,255,.64); }
.dark-section .eyebrow { color: var(--cyan); }
.dark-section .kicker-card { border-color: rgba(255,255,255,.28); }
.dark-section .kicker-card p { color: rgba(255,255,255,.62); }

.pipeline-list { margin-top: 3.5rem; border-top: 1px solid var(--line); }
.pipeline-row { display: grid; grid-template-columns: .24fr 1.2fr .8fr .8fr .45fr; gap: 1rem; align-items: center; padding: 1.35rem .8rem; border-bottom: 1px solid var(--line); transition: background .2s ease; }
.pipeline-row:hover { background: var(--white); }
.pipeline-row .code { color: var(--blue); font-size: .76rem; font-weight: 800; letter-spacing: .08em; }
.pipeline-row h3 { margin: 0; font-family: Georgia, serif; font-size: 1.35rem; font-weight: 400; }
.pipeline-row span { color: var(--muted); font-size: .87rem; }
.stage { display: inline-flex; justify-self: start; padding: .35rem .65rem; border: 1px solid var(--line); border-radius: 999px; color: var(--ink) !important; font-size: .72rem !important; font-weight: 800; }
.stage.discovery { border-color: rgba(95,130,255,.42); color: var(--blue) !important; }
.stage.preclinical { border-color: rgba(250,140,121,.55); color: #c45a4d !important; }
.stage.clinical { border-color: rgba(77,163,122,.55); color: #277a53 !important; }
.pipeline-row .arrow { text-align: right; color: var(--blue); }

.timeline { margin-top: 3rem; position: relative; }
.timeline::before { content: ""; position: absolute; left: 7px; top: 0; bottom: 0; width: 1px; background: var(--line); }
.timeline-item { display: grid; grid-template-columns: 45px 1fr; gap: 1.5rem; margin-bottom: 2.4rem; }
.timeline-dot { width: 15px; height: 15px; margin-top: .35rem; border: 4px solid var(--paper); background: var(--blue); border-radius: 50%; box-shadow: 0 0 0 1px var(--blue); position: relative; z-index: 1; }
.timeline-item h3 { margin: 0 0 .35rem; font-family: Georgia, serif; font-size: 1.4rem; font-weight: 400; }
.timeline-item p { max-width: 590px; margin: 0; color: var(--muted); }

.news-grid { display: grid; grid-template-columns: repeat(3, 1fr); gap: 1rem; }
.news-card { display: flex; min-height: 280px; flex-direction: column; justify-content: space-between; padding: 1.7rem; background: var(--white); border: 1px solid var(--line); transition: transform .25s var(--ease-out), box-shadow .25s var(--ease-out); }
.news-card:hover { transform: translateY(-5px); box-shadow: var(--shadow); }
.news-type { color: var(--blue); font-size: .72rem; font-weight: 800; letter-spacing: .13em; text-transform: uppercase; }
.news-card h3 { margin: 3rem 0 0; font-family: Georgia, serif; font-size: 1.65rem; font-weight: 400; line-height: 1.08; }
.news-card time { color: var(--muted); font-size: .78rem; }
.news-footer { display: flex; align-items: center; justify-content: space-between; margin-top: 1.6rem; padding-top: 1rem; border-top: 1px solid var(--line); }
.news-footer a { color: var(--blue); font-size: .8rem; font-weight: 800; }
.filters { display: flex; flex-wrap: wrap; gap: .6rem; margin: 2.5rem 0 1.3rem; }
.filter { padding: .58rem .9rem; border: 1px solid var(--line); background: transparent; border-radius: 999px; color: var(--muted); cursor: pointer; font-size: .78rem; font-weight: 700; }
.filter.active, .filter:hover { border-color: var(--blue); background: var(--blue); color: var(--white); }
.news-card.is-hidden { display: none; }

.contact-grid { display: grid; grid-template-columns: .85fr 1.15fr; gap: 2rem; align-items: stretch; }
.contact-panel { padding: clamp(2rem, 5vw, 4rem); background: var(--navy-900); color: var(--white); }
.contact-panel p { color: rgba(255,255,255,.66); }
.contact-list { display: grid; gap: 1.25rem; margin-top: 3rem; }
.contact-item small { display: block; margin-bottom: .25rem; color: var(--cyan); font-size: .68rem; font-weight: 800; letter-spacing: .12em; text-transform: uppercase; }
.contact-item a, .contact-item span { color: rgba(255,255,255,.9); font-size: .94rem; }
.form-panel { padding: clamp(2rem, 5vw, 4rem); background: var(--white); border: 1px solid var(--line); }
.form-grid { display: grid; grid-template-columns: 1fr 1fr; gap: 1.25rem; }
.field { display: grid; gap: .45rem; }
.field.full { grid-column: 1 / -1; }
.field label { color: var(--ink); font-size: .76rem; font-weight: 800; letter-spacing: .05em; text-transform: uppercase; }
.field input, .field textarea, .field select { width: 100%; border: 1px solid var(--line); background: var(--paper); padding: .8rem .9rem; color: var(--ink); border-radius: 0; outline: none; transition: border .2s ease, box-shadow .2s ease; }
.field textarea { min-height: 130px; resize: vertical; }
.field input:focus, .field textarea:focus, .field select:focus { border-color: var(--blue); box-shadow: 0 0 0 3px rgba(95,130,255,.13); }
.form-panel .btn { margin-top: 1.2rem; }
.form-note { color: var(--muted); font-size: .78rem; }
.form-success { display: none; margin-top: 1rem; padding: .75rem .9rem; background: #ebf8ef; color: #1e7546; font-size: .85rem; }
.form-success.show { display: block; }

.accordion { border-top: 1px solid var(--line); margin-top: 2.6rem; }
.faq-item { border-bottom: 1px solid var(--line); }
.faq-trigger { width: 100%; display: flex; justify-content: space-between; gap: 1rem; padding: 1.2rem 0; background: none; color: var(--ink); text-align: left; font-family: Georgia, serif; font-size: 1.3rem; cursor: pointer; }
.faq-trigger span:last-child { color: var(--blue); font-family: Inter, sans-serif; font-size: 1.4rem; }
.faq-content { display: none; max-width: 650px; padding: 0 0 1.3rem; color: var(--muted); font-size: .94rem; }
.faq-item.open .faq-content { display: block; }

.site-footer { padding: 3.5rem 0 1.5rem; background: var(--navy-950); color: var(--white); }
.footer-top { display: grid; grid-template-columns: 1.3fr 1fr 1fr 1fr; gap: 2rem; padding-bottom: 3rem; }
.footer-brand p { max-width: 260px; margin-top: 1.3rem; color: rgba(255,255,255,.52); font-size: .86rem; }
.footer-col h3 { margin: 0 0 1rem; color: var(--cyan); font-size: .7rem; letter-spacing: .15em; text-transform: uppercase; }
.footer-col a { display: block; width: fit-content; margin: .55rem 0; color: rgba(255,255,255,.68); font-size: .84rem; }
.footer-col a:hover { color: var(--white); }
.footer-bottom { display: flex; justify-content: space-between; gap: 1rem; padding-top: 1.4rem; border-top: 1px solid rgba(255,255,255,.14); color: rgba(255,255,255,.42); font-size: .72rem; }
.footer-bottom p { margin: 0; }

.reveal { opacity: 0; transform: translateY(18px); transition: opacity .65s var(--ease-out), transform .65s var(--ease-out); }
.reveal.visible { opacity: 1; transform: translateY(0); }
.delay-1 { transition-delay: .08s; } .delay-2 { transition-delay: .16s; } .delay-3 { transition-delay: .24s; }

@media (max-width: 900px) {
  .container { width: min(100% - 2rem, 720px); }
  .section { padding: 5.5rem 0; }
  .nav-links { gap: 1rem; }
  .split, .split.reverse, .contact-grid { grid-template-columns: 1fr; gap: 2.4rem; }
  .stats { grid-template-columns: repeat(2, 1fr); }
  .feature-grid, .news-grid { grid-template-columns: 1fr 1fr; }
  .footer-top { grid-template-columns: 1.4fr 1fr 1fr; }
  .footer-brand { grid-column: 1 / -1; }
}
@media (max-width: 680px) {
  .container, .narrow { width: min(100% - 2rem, 520px); }
  .site-header { background: rgba(6,19,38,.65); }
  .site-header.scrolled { background: rgba(247,249,252,.96); }
  .menu-toggle { display: block; }
  .nav-links { position: fixed; inset: 86px 0 0; display: grid; align-content: start; gap: 0; padding: 1.5rem 1rem; background: var(--navy-950); transform: translateX(100%); transition: transform .25s var(--ease-out); }
  .site-header.scrolled .nav-links { background: var(--paper); }
  .nav-links.open { transform: translateX(0); }
  .nav-links a { padding: 1rem 0; border-bottom: 1px solid rgba(255,255,255,.13); font-size: 1rem; }
  .site-header.scrolled .nav-links a { border-color: var(--line); }
  .nav-links a[aria-current="page"]::after { bottom: .75rem; left: auto; width: 24px; right: 0; }
  .nav-cta { display: inline-flex; width: fit-content; margin-top: 1rem; border: 1px solid currentColor !important; padding: .7rem 1rem !important; }
  .hero { min-height: 730px; background-position: 64% center; }
  .hero::before { background: linear-gradient(90deg, rgba(6,19,38,.99), rgba(6,19,38,.65)); }
  .hero-inner { padding: 10rem 0 4.5rem; }
  .hero h1 { font-size: clamp(3.2rem, 16vw, 5rem); }
  .hero-meta { margin-top: 3.5rem; gap: 1rem; }
  .hero-meta > div { width: 42%; }
  .feature-grid, .news-grid { grid-template-columns: 1fr; }
  .stats { gap: 1.5rem 1rem; }
  .stat { padding-left: .8rem; }
  .pipeline-row { grid-template-columns: .25fr 1fr auto; }
  .pipeline-row > span:not(.stage), .pipeline-row .stage { grid-column: 2; }
  .pipeline-row .arrow { grid-column: 3; grid-row: 1 / span 2; }
  .form-grid { grid-template-columns: 1fr; }
  .field.full { grid-column: auto; }
  .footer-top { grid-template-columns: 1fr 1fr; }
  .footer-brand { grid-column: 1 / -1; }
  .footer-bottom { flex-direction: column; }
}
@media (prefers-reduced-motion: reduce) {
  *, *::before, *::after { scroll-behavior: auto !important; animation-duration: .001ms !important; transition-duration: .001ms !important; }
}